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Introduction: With the latest outbreak of corona virus COVID-19 and with a number of previous retro (RNA) virus’ outbreaks like HIV, SARS and a new coronavirus associated with human respiratory disease in China. there is the question if it is possible to design a universal retroviral

Introduction: With the latest outbreak of corona virus COVID-19 and with a number of previous retro (RNA) virus’ outbreaks like HIV, SARS and a new coronavirus associated with human respiratory disease in China. there is the question if it is possible to design a universal retroviral

vaccine or even cure. So far vaccines have been based on immune response to certain protein or DNA/RNA sequence within the virus. As many viruses, particularly retroviruses, have extremely variable genome sequence, such an approach has not been successful. For example, there is still not a generally successful vaccine for HIV virus and in the case of influenza, virus vaccines exist for each strain separately. During this rapid research effort, we will identify the common component of proteins responsible for initial infection for all related RNA viruses and then design a vaccine based on this component and thus create the cure.

vaccine or even cure. So far vaccines have been based on immune response to certain protein or DNA/RNA sequence within the virus. As many viruses, particularly retroviruses, have extremely variable genome sequence, such an approach has not been successful. For example, there is still not a generally successful vaccine for HIV virus and in the case of influenza, virus vaccines exist for each strain separately. During this rapid research effort, we will identify the common component of proteins responsible for initial infection for all related RNA viruses and then design a vaccine based on this component and thus create the cure.

For that purpose, we will utilize the Resonant Recognition Model (RRM), which proposes that protein biological function is characterized by certain periodicities (frequencies) within distribution of free electron energies along protein. The RRM is capable of identifying common

For that purpose, we will utilize the Resonant Recognition Model (RRM), which proposes that protein biological function is characterized by certain periodicities (frequencies) within distribution of free electron energies along protein. The RRM is capable of identifying common

characteristics for proteins having the same biological function/interaction, but not necessarily having high level of homology. We have previously successfully utilized the RRM model in analysis of HIV virus, where we have identified common RRM characteristic for all different and very variable strains of HIV virus. Based on this characteristic we have designed and experimentally tested peptides that will be used in universal vaccine for all HIV strains.

characteristics for proteins having the same biological function/interaction, but not necessarily having high level of homology. We have previously successfully utilized the RRM model in analysis of HIV virus, where we have identified common RRM characteristic for all different and very variable strains of HIV virus. Based on this characteristic we have designed and experimentally tested peptides that will be used in universal vaccine for all HIV strains.

COR 19: Corona viruses are retroviruses, enveloped viruses with positive-sense single-stranded RNA genome, which is the largest among known RNA viruses. The retrovirus is a type of RNA virus that inserts a copy of its genome into the DNA of a host cell that it invades, thus changing

COR 19: Corona viruses are retroviruses, enveloped viruses with positive-sense single-stranded RNA genome, which is the largest among known RNA viruses. The retrovirus is a type of RNA virus that inserts a copy of its genome into the DNA of a host cell that it invades, thus changing

the genome of that cell. In most viruses, DNA is transcribed into RNA, and then RNA is translated into protein. However, retroviruses function differently, as their RNA is reverse transcribed into DNA and integrated into the host cell's genome (when it becomes a provirus), and then undergoes the usual transcription and translational processes to express the genes carried by the virus. The information contained in a retroviral gene is thus used to generate the corresponding protein via the sequence: RNA → DNA → RNA → polypeptide. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backwards). The new DNA is then incorporated into the host cell genome by an integrase enzyme, at which point the retroviral DNA is referred to as a provirus.

the genome of that cell. In most viruses, DNA is transcribed into RNA, and then RNA is translated into protein. However, retroviruses function differently, as their RNA is reverse transcribed into DNA and integrated into the host cell's genome (when it becomes a provirus), and then undergoes the usual transcription and translational processes to express the genes carried by the virus. The information contained in a retroviral gene is thus used to generate the corresponding protein via the sequence: RNA → DNA → RNA → polypeptide. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backwards). The new DNA is then incorporated into the host cell genome by an integrase enzyme, at which point the retroviral DNA is referred to as a provirus.