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<sup>1</sup>Department of Experimental Medicine, Second University of Naples, Naples, Italy Centre for Autism - La Forza del Silenzio, Caserta, Italy Cancellautismo - Non-profit Association for Autism Care, Florence, Italy dariosin@uab.edu.<br><sup>2</sup> R.E.D. Laboratories, Zellik, Belgium.<br><sup>3</sup>Biomedical Centre for Autism Research and Treatment, Bari, Italy.<br><sup>4</sup>Department of Internal Medicine, Faculty of Medicine, Masaryk University, Brno, Czech Republic Laboratory of Structural Biology and Proteomics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.<br><sup>5</sup> Nevada Center for Biomedical Research, Reno, NV, U.S.A.<br><sup>6</sup>Himmunitas vzw, Brussels, Belgium.
<sup>1</sup>Department of Experimental Medicine, Second University of Naples, Naples, Italy Centre for Autism - La Forza del Silenzio, Caserta, Italy Cancellautismo - Non-profit Association for Autism Care, Florence, Italy dariosin@uab.edu.<br><sup>2</sup> R.E.D. Laboratories, Zellik, Belgium.<br><sup>3</sup>Biomedical Centre for Autism Research and Treatment, Bari, Italy.<br><sup>4</sup>Department of Internal Medicine, Faculty of Medicine, Masaryk University, Brno, Czech Republic Laboratory of Structural Biology and Proteomics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.<br><sup>5</sup> Nevada Center for Biomedical Research, Reno, NV, U.S.A.<br><sup>6</sup>Himmunitas vzw, Brussels, Belgium.
<ref>https://www.ncbi.nlm.nih.gov/pubmed/26912817</ref>.
<ref>https://www.ncbi.nlm.nih.gov/pubmed/26912817</ref>.
RESULTS:br>A reduction of CD57(+)CD3(-) lymphocyte count was recorded in a significant number of patients with autism.<br>DISCUSSION AND CONCLUSION:<br>We demonstrated that the number of peripheral CD57(+)CD3(-) cells in children with autism often falls below the clinically accepted normal range. This implies that a defect in the counter-regulatory functions necessary for balancing pro-inflammatory cytokines exists, thus opening the way to chronic inflammatory conditions associated with ASD.
Traduction:<br>RÉSULTATS:<br>Une réduction du nombre de lymphocytes CD57 (+) CD3 (-) a été enregistrée chez un nombre significatif de patients atteints d'autisme.<br>DISCUSSION ET CONCLUSION:<br>Nous avons démontré que le nombre de cellules CD57 (+) CD3 périphériques (-) chez les enfants atteints d'autisme tombe souvent en dessous de la gamme normale généralement acceptée. Cela implique qu'il existe un défaut dans les fonctions de contre-régulation nécessaires à l'équilibre des cytokines pro-inflammatoires, ce qui ouvre la voie aux maladies inflammatoires chroniques associées aux TSA [troubles du Spectre Autistique].
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